Functional connectivity in in vitro neuronal assemblies
نویسندگان
چکیده
Complex network topologies represent the necessary substrate to support complex brain functions. In this work, we reviewed in vitro neuronal networks coupled to Micro-Electrode Arrays (MEAs) as biological substrate. Networks of dissociated neurons developing in vitro and coupled to MEAs, represent a valid experimental model for studying the mechanisms governing the formation, organization and conservation of neuronal cell assemblies. In this review, we present some examples of the use of statistical Cluster Coefficients and Small World indices to infer topological rules underlying the dynamics exhibited by homogeneous and engineered neuronal networks.
منابع مشابه
The functional structure of cortical neuronal networks grown in vitro
We apply an information theoretic treatment of action potential time series measured with microelectrode arrays to estimate the connectivity of mammalian neuronal cell assemblies grown in vitro. We infer connectivity between two neurons via the measurement of the mutual information between their spike trains. In addition we measure higher point multi-informations between any two spike trains co...
متن کاملFunctional structure of cortical neuronal networks grown in vitro.
We apply an information-theoretic treatment of action potential time series measured with microelectrode arrays to estimate the connectivity of mammalian neuronal cell assemblies grown in vitro. We infer connectivity between two neurons via the measurement of the mutual information between their spike trains. In addition we measure higher-point multi-information between any two spike trains, co...
متن کاملConstrained synaptic connectivity in functional mammalian neuronal networks grown on patterned surfaces.
The use of ordered neuronal networks in vitro is a promising approach to study the development and the activity of small neuronal assemblies. However, in previous attempts, sufficient growth control and physiological maturation of neurons could not be achieved. Here we describe an original protocol in which polylysine patterns confine the adhesion of cellular bodies to prescribed spots and the ...
متن کاملMethadone restores local and remote EEG functional connectivity in opioid-dependent patients.
Currently it has been proposed that normal brain function is critically dependent upon a dynamical balance between functions of local neuronal assemblies and global integrative processes. A loss of such metastable balance in favor of either independent or hyper-ordered processing is considered as the reflection of a brain disease. It has been shown that opioid dependence can be characterized as...
متن کاملDevelopment of a partial correlation algorithm to estimate functional connectivity in cortical networks
Introduction Since the nineteenth century, we know that the neuronal elements of the brain constitute a formidably complex structural network (Bullmore et al, 2009). While a large number of anatomical studies of the human brain have been carried out, there is little information about the organization and function of neural networks (Sporns et al, 2005). In the last years, one of the major issue...
متن کامل